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Roger Yonchien Tsien (traditional Chinese: 錢永健; simplified Chinese: 钱永健; born February 1, 1952) is a Chinese-American biochemist and a professor at the Department of Chemistry and Biochemistry, University of California, San Diego. He was awarded one third of the Nobel Prize in chemistry 2008 "for his discovery and development of the Green Fluorescent Protein, GFP" with two other chemists.4 B3 w* U& D0 N# _
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Roger Y. Tsien was born in New York, in 1952. He grew up in Livingston, New Jersey and attended Livingston High School there. He had a number of engineers in his extended family, including his father who was a mechanical engineer and his mother's brothers who were engineering professors at MIT. Tsien, who calls his own work molecular engineering, once said, "I'm doomed by heredity to do this kind of work".
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Tsien suffered from asthma as a child, and as a result, he was often indoors. He spent hours conducting chemistry experiments in his basement laboratory. When he was 16, he won first prize in the nationwide Westinghouse talent search with a project investigating how metals bind to thiocyanate.; v( i# u# B8 y$ O
9 p, g+ x) F2 D7 D0 \- @8 j: bHe attended Harvard University on a National Merit Scholarship and graduated with a Bachelor of Science in chemistry and physics in 1972. He graduated with summa cum laude. After completing his bachelor's degree, he joined the Physiological Laboratory at the University of Cambridge in Cambridge, England with the aid of a Marshall Scholarship. He received his Ph.D in physiology from the University of Cambridge in 1977. He was a Research Fellow in Gonville and Caius College, University of Cambridge from 1977 to 1981.0 p- u; A' r& x+ {
: T: y& { ?% L: y [- lAfter completing his PhD at Cambridge University, he was appointed to the faculty at the University of California, Berkeley from 1982 to 1989. Since 1989 he has been working at the University of California, San Diego, as Professor of Pharmacology and Professor of Chemistry and Biochemistry, and an investigator of the Howard Hughes Medical Institute.
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Tsien is renowned for revolutionizing the fields of cell biology and neurobiology by allowing scientists to peer inside living cells and watch the behavior of molecules in real time. He is well-known for developing colorful dyes, such as Fura-2, to track the movement of calcium within cells and has genetically modified molecules that make jellyfish and corals glow, creating fluorescent colors in a dazzling variety of hues. These multicolored fluorescent proteins are used by scientists to track where and when certain genes are expressed in cells or in whole organisms.$ `- C* M+ {. p
% t' D. E8 ]- r& @ e/ ^In 2004, Tsien was awarded the Wolf Prize in Medicine for "for his seminal contribution to the design and biological application of novel fluorescent and photolabile molecules to analyze and perturb cell signal transduction." In 2006 he became a Foreign Fellow of the Royal Society in the UK.
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( z$ ~) i4 K. fIn 2008, Tsien shared the Nobel Prize in Chemistry with Osamu Shimomura and Martin Chalfie for "The Green Fluorescent Protein: Discovery, Expression and Development". |
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发表于 2008-10-8 07:43
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发表于 2008-10-8 10:56
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